Frequent Questions

What is TOMORROW Prenatal Test?

TOMORROW Prenatal Test, is the new CGC Genetics test that with a non-invasive technique and from a simple blood sample detects, as early as 10 weeks of pregnancy:
• The most common fetal aneuploidies: trisomies 21, 18 and 13;
• Fetal gender identification;
• Sex chromosome aneuploidies: Monosomy X, XXX, XXY and XYY.

 

Can TOMORROW Prenatal Test be performed in case of a twin pregnancy?

Yes, in case of a twin pregnancy (2 fetuses), TOMORROW Prenatal Test analyses the presence of trisomies 21, 18 and 13, but it is not able to detect sex chromosome aneuploidies.

TOMORROW Non Invasive Prenatal Test cannot be performed in case of pregnancies with more than two fetuses.

Fetal gender identification is performed by detecting the presence or absence of Y chromosome in maternal blood. In case of Y chromosome detection in twin pregnancy (2 fetuses), it is not possible to confirm if one or both fetuses are male.

If there is a history of vanishing fetus, please indicate in the appropriate section on the Requisition Form.

 

Can TOMORROW Prenatal Test be performed in case of an IVF pregnancy?

Yes, TOMORROW Prenatal Test can be performed in case of pregnancies by IVF, both with self-donation of eggs or not.
If there is a history of vanishing fetus, please indicate in the appropriate section on the Requisition Form

 

What are the requirements needed to perform TOMORROW Prenatal Test?

TOMORROW Prenatal Test is clinically validated to be performed from 10 weeks and 0 days of pregnancy, as estimated by LMP, CRL or other clinically appropriate method (equivalent to 8 weeks of fetal age, if determined by date of conception).

What type of sample is needed to perform TOMORROW Prenatal Test and what are the shipping conditions?

A simple maternal blood sample (7-10 mL) in STRECK tube (ref: Cell-Free DNA BCT© CE) is needed, collected at any time of the day and without prior preparation.

Make sure delivery arrives within 4 days after blood sampling and that is addressed to:

CGC Genetics
Rua Sá da Bandeira, 706-1º
4000-432 Porto, Portugal

What type of result can be obtained with TOMORROW Prenatal Test?

TOMORROW Prenatal Test analyses the most common fetal aneuploidies: trisomies 21, 18 and 13, identifies fetal gender and detects sex chromosome aneuploidies (Monosomy X, XXX, XXY and XYY).

Possible results:
“Not detected”, in case there is a highly reduced probability for the tested aneuploidies;
“Detected”, in case there is a highly increased probability for the tested aneuploidies;
Fetal Gender: Female (XX), Male (XY).

 

What to do in case of a positive result?

In case of a positive result (“detected”), according to ACOG, ACMG and SMFM*, confirmation by invasive prenatal diagnosis is recommended by amniocentesis or chorionic villus sampling, and chromosomal analysis by FISH, QF PCR or karyotyping.

In this case, CGC Genetics offers at no additional cost, the analysis by QF-PCR, to detect numerical changes of chromosomes 21, 18, 13, X and Y, with results in the shortest time possible (24-48h), as well as cytogenetic chromosomal analysis, in a fetal sample.

IT IS RECOMMEND THAT NO IRREVERSIBLE CLINICAL DECISION IS TAKEN UNIQUELY BASED ON THE RESULT OF THIS TEST.

*ACOG – American College of Obstetricians and Gynecologists; ACMG – American College of Medical Genetics and Genomics; SMFM – Society for Maternal-Fetal Medicine.

When can I expect TOMORROW Prenatal Test results to be available?

Average turnaround time: 6 business days (maximum 10) and the results will be sent directly to the ordering healthcare professional.

What is a false positive or false negative rate of TOMORROW Prenatal Test?

TOMORROW Prenatal Test, like any other test type has an inherent error rate, although it is much reduced. The combined rate of false positive and false negative is less than 0.5%.

A false positive result means that even though the test result is of highly increased risk (“detected”) for a specific tested aneuploidy, this in reality is not present in the fetus, but it might be present, for example, only in the placenta (placental mosaicism).

A false negative means that the test result has been presented as of highly reduced risk (“not detected”), but the fetus presents one of the tested aneuploidies. This error is the less frequent, having a probability of occurrence of 0.03% for trisomies 21, 18 and 13.

For more information on the clinical studies performed so far, please visit the publications list available

 

Do you have any other questions?

CONTACT US

customercare@cgcgenetics.com

+351 223 389 900